摘要
目的探讨宫颈鳞状细胞癌中HPV感染和p16表达的情况及临床相关性。方法用免疫组化的方法对54例宫颈鳞癌组织中HPV感染和p16的表达情况进行检测。结果HPV感染的阳性率为96.29%(52/54),p16的阳性率为66.66%(36/54)。结论HPV感染与p16的表达有关;HPV感染与临床分期、癌细胞的分化程度、肿瘤的淋巴结转移情况无关;p16的表达与癌细胞的分化程度、肿瘤的淋巴结转移情况有关,与分期无关。
Objective To investigate the states of HPV infection and p16 expression in cervical squamous cell carcinoma,and to study the relationship between them and clinical features. Methods Fifty-four specimens of cervical squamous cell carcinoma were applied to detect the states of HPV infection and expression of p16 by immunohistochemical methods. Results The positivity rate of HPV infection was 96.29%（52/54）, while that of the p16 expression was 66.66%（36/54）. Conclusion The infection of HPV has relative to the p16 expression. HPV infection has no relationship with cell differentiation,clinical type,clinical stage and lymph node metastasis, p16 expression has relationship with the degree of tumor cell differentiation and lymphnode metastasis.
出处
《中国现代医生》
2009年第4期3-4,38,F0003,共4页
China Modern Doctor
