羟苯磺酸钙治疗马兜铃酸肾病疗效观察

Clinical Effect of Calcium Dobesilate on Treating Arisolochic Acid Nephrapathy

目的观察羟苯磺酸钙(安多明)对马兜铃酸肾病的临床疗效。方法48例AAN患者随机分为两组,观察组(n=26)在常规综合治疗的基础上加用羟苯磺酸钙0.5g,每日3次,口服;对照组(n=22)单纯常规治疗。观察治疗前后组间24小时尿蛋白定量、尿素氮、血肌酐等的变化。结果治疗后观察组24小时尿蛋白定量、尿素氮、血肌酐水平均较对照组明显下降(P<0.05)。结论羟苯磺酸钙可以降低AAN患者的尿蛋白排泄量,改善AAN患者的肾功能。

Objective To observe the effect of calcium dobesilate on arisolochic acid nephrapathy（AAN）. Methods Forty-eight patients with AAN were randomly divided into two groups. Twenty-six cases received calcium dobesilate （0.5 g,three times a day） plus routine methods,were the treated group （n=26）. The others were consist of control group only received routine therapeutics （n=22）. The concentrations of Urinary protein,serum creatinine and BUN had been measured after 8 weeks of study. Results Urinary protein, serum creatinine and BUN decreased significandy in both groups. Comparing to control group,the Urinary protein,serum creatinine and BUN reduced much lower than those of calcium dobesilate treated group. Conclusion Calcium dobesilate can meliorated urinary protein excretion and promoted the renal function of patients with AAN.