HPV6b感染与新疆哈萨克族食管癌的关系

Relationship between HPV6b infection and esophageal cancer in Kazakh in Xinjiang Uygur Autonomous Region

目的:探讨人乳头状瘤病毒6b(human papilloma virus6b,HPV6b)的感染与新疆哈萨克族食管癌的关系.方法:收集哈萨克族食管癌标本120例,按同性别、同民族、年龄相差小于5岁、同一个居住地选取对照120例.运用假病毒中和实验(PsV neutralization assay)检测血清中HPV6b感染率.结果:食管癌组HPV6b感染率为27.5%,对照组感染率为22.5%,两组差别无统计学意义(χ2=0.80,P=0.37).食管癌组与对照组不同性别HPV6b感染率差异均无统计学意义(χ2=0.31,0.01,P=0.58,0.92).食管癌组<50岁,50-59岁,60-69岁以及≥70岁年龄组HPV6b感染率分别为31.0%,29.0%,20.9%和35.3%,差异无统计学意义(χ2=1.67,P=0.64),对照组中分别为19.4%,13.5%,30.6%和31.3%,差异亦无统计学意义(χ2=3.93,P=0.27).结论:HPV6b感染在哈萨克族人群中普遍存在,哈萨克族食管癌的发生与HPV6b感染无相关性.

AIM： To evaluate the association between HPV6b infection and esophageal cancer （EC） in Kazakh of Xinjiang, China. METHODS： A case-control study was conducted with 120 cases of EC and 120 controls. The controls were matched by sex, nationality, area of residence and age difference within 5 years. HPV6b infection was identified by PsV neutralization assay from blood-serum. Chi-square was performed to identify risk factors. RESULTS： The esophageal cancer infection rate was 27.5% in the cases while it was 22.5% in the controls. Infection rate of esophageal cancer in experiment group was not statistically different from the controls （X^2 = 0.80, P = 0.371）. HPV6b infection rate of the males was not statistically different from the females in both the cases and the controls （2 = 0.31, 0.01, P = 0.58, 0.92）. The infection rates of HPV6b in 〈 50, 50-59, 60-69 and ≥ 70 age groups, were 31.0%, 29.0%, 20.9% and 35.3%, respectively with no statistical differences detected among these groups in EC group （X^2 = 1.67, P = 0.64）. The infection rates of HPV6b were 19.4%, 13.5%, 30.6% and 31.3%, respectively in the controls with no statistical differences either （X^2 = 3.93, P = 0.27）. CONCLUSION： The infection of HPV6b is common. The EC in Kazakh of Xinjiang has no association with HPV6b infection.