培哚普利对冠心病合并阵发性心房颤动患者P波离散度的影响

The Influence of Perindopril on P Dispersion of Patients with Coronary Heart Disease and Atrial Fibrillation

目的探讨血管紧张素转化酶抑制剂培哚普利对冠心病合并阵发性心房颤动(AF)P波离散度、最大P波时限及AF发生率的影响。方法58例冠心病合并房颤患者,随机分成两组,治疗组29例、对照组29例。治疗组给予培哚普利干预,观察培哚普利对P波离散度、最大P波时限及AF发生率的影响。结果治疗组3个月后Pd、Pmax明显减小,AF的发生率较对照组亦明显降低。结论ACEI可减小Pd、Pmax,同时部分预防AF的发生。

Objective To investigate the influence of perindopril on P dispersion（Pd）,maximal time of waves（Pmax）and recurrence rate of atrial fibriUation（AF）, Methods 58 patients,who had organic heart diseases combined with AF,were divided into two groups at random：the experiment group included 29 patients;the contrast group included 29 patients. The patients from experiment group took perindopril,and observed the influence of perindopril on Pd,Pmax and recurrence of AF. Results After 3 months the Pd and Pmax decreased,and the recurrence rate of AF obviously decreased compared with the contrast group too. Conclusion ACEI can dicrease Pd and Pmax, and at the same time can prevent the recurrence of AF.