十二指肠溃疡、慢性糜烂性胃炎患者胃窦粘膜一氧化氮含量及一氧化氮合酶活力研究

Study on nitric oxide product and nitric oxide synthase activity of gastric mucosa in patients with duodenal ulcer or chronic erosiye gastritis

对19例十二指肠球部溃疡及19例慢性糜烂性胃炎患者胃窦粘膜的一氧化氮（NO）与一氧化氮合酶（NOS）进行定量检测并与正常人比较，结果显示：十二指肠溃疡及慢性糜烂性胃炎患者胃粘膜的NO含量升高、NOS活力增强（P值均＜0．01）。提示：胃、十二指肠粘膜的损伤或炎症可能与胃粘膜NOS过度表达、NO产生过多有关。

Quantitative analysis of gastric antralmucosa was performed in 19 duodenal ulcer and 19chronic erosive gastritis patients. and compared withl I normal persons. Results showed nitric oxide (NO)product and nitric oxide synthase (NOS) activity inexperimental groups was higher than that in normalsubjects (<0.01). These findings suggest that thedamage or inflammation in mucosa of stomach andduodenum might be related to the raising of NO andNOS in gastric mucosa.