益生菌对缓解期溃疡性结肠炎的维持缓解作用

Prophylactic Effects of Probiotics on the Inactive Ulcerative Colitis

目的观察口服益生菌即双歧、嗜酸乳杆菌,肠球菌三联活菌胶囊对缓解期溃疡性结肠炎(UC)的维持缓解作用,比较美沙拉秦与双歧、嗜酸乳杆菌,肠球菌三联活菌胶囊对维持缓解期UC的疗效。方法采用随机对照方法观察78例活动期UC经治疗后处于缓解期的患者,给予美沙拉秦钠或口服双歧、嗜酸乳杆菌,肠球菌三联活菌胶囊,疗程为1a。结果治疗1年末,口服双歧、嗜酸乳杆菌,肠球菌三联活菌胶囊组维持缓解率为69.44%,复发率为30.56%;美沙拉秦组维持缓解率为72.22%,复发率为27.78%;2组复发率相比,差异无统计学意义(P>0.05)。结论口服双歧、嗜酸乳杆菌,肠球菌三联活菌胶囊对缓解期UC维持缓解有较好的疗效,与美沙拉秦的疗效相近。

[Objective] To observe the prophylactive effects of the combined bifidobacterium, lactobacillus and Enterococcus capsule on the inactive ulcerative colitis （UC）, and compare the effect with mesalazine. [ Methods ] A randomized controlled clinical trial was conducted on 78 patients with ulcerative colitis in remission stage. The patients were treated orally with combined bifidobacterium, lactobacillus and enterococeus capsule for 1-year course. [ Results] After 1 year of treatment, prophylactive rate and recurrence rate of the group treated with the combined capsule was 69.44%, 30.56% respectively; that of the mesalazine group was 72.22%, 27.78% respectively. The difference of recurrence rate between the 2 groups was not significant （P 〉 0.05）. [ Conclusion] The combined bifidobacterium lactobacillus and enterococcus capsule shows prophylactic effects on the inactive ulcerative colitis, which is comparative to mesalazine capsule.