高脂血症患者的下肢动脉血流动力学改变的研究

Change of hemodynamics in lower limb artery of patients with hyperlipoidemia

目的:研究高脂血症对下肢动脉血流动力学的影响。方法:选择我院2005年7月至2007年3月间的111例患者,按其血脂水平分为四组:正常对照组(Ⅰ组),高甘油三酯血症组(Ⅱ组),高胆固醇血症组(Ⅲ组),混合性高脂血症组(Ⅳ组)。抽取空腹肱静脉血进行血脂测定,同时应用多功能周围血管检查仪分别获取双侧股动脉、股浅动脉、腘动脉、胫后动脉、足背动脉的收缩期最大血流速度(Vmax),阻力指数(RI),搏动指数(PI),并将结果用SPSS 10.0进行统计分析。结果:按多功能周围血管检查仪检测的下肢动脉血流动力学参数异常率的高度排列依次为:(1)Ⅱ、Ⅲ、Ⅳ组的股浅动脉的PI;(2)Ⅱ、Ⅳ组的股动脉PI;(3)Ⅳ组的足背动脉的PI;(4)Ⅱ、Ⅳ组的胫后动脉RI;(5)Ⅳ组足背动脉的Vmax显著高于正常对照组(P<0.05)。结论:混合性高脂血症对下肢动脉的血流动力学影响最大,股浅动脉、股动脉、胫后动脉和足背动脉较易受高血脂的影响而发生动脉硬化。

Objective： To determine the influence of hyperlipoidemia on hemodynamics of lower extremity arteries. Methods： A total of 111 patients who visited our hospital during July 2005 to March 2007 were chosen, and randomly were separated to four groups： Normal control group （group I ）, hypertriglyceridemia group （group Ⅱ ）, hyperchob esteremia group （group Ⅲ） and combined hyperlipidemia group （group Ⅳ）. The fasting plasma lipid was detected. Moreover, Personal vascular laboratory （PVL） was applied to the four group patient. The follow data including maxi-mum velocity （Vmax）, resistance index （RI）, pulsating index （PI） of lower extremity artery at femoral artery, superficial femoral artery, popliteal artery, posterior tibial artery and dorsalis pedis artery were all taken. Results： The exam- ined results of PVL were： （1） the PI of superficial femoral artery in group Ⅱ, Ⅲ , and Ⅳ ; （2） the PI of superficial femoral artery in group H and IV ; （3） the PI of dorsalis pedis artery in group Ⅳ;（4） the RI of posterior tibial artery in group Ⅱ and Ⅳ; （5） Vmax of dorsalis pedis artery in group IV is higher than those of normal control group （P〈0.05）. Concision： The combined hyperlipidemia have most influence than the others hyperlipidemia. The superficial femoral artery, femoral artery, posterior tibial artery and dorsalis pedis artery can be more easily influenced to cause angiosclerosis.