2005-2007年吉大一院神经外科鲍曼不动杆菌临床耐药性分析

Analysis on Resistance Profile of Infections of Acinetobacter Baumannii in 1st Hospital of Jilin University from 2005 to 2007

目的了解吉林大学第一医院神经外科临床分离的鲍曼不动杆菌临床感染耐药现状。方法收集吉大一院2005年1月至2007年12月的神经外科临床标本进行细菌培养鉴定及药敏分析,采用SPSS统计软件分析试验结果。结果三年间共分离鲍曼不动杆菌47株,感染率居第二位(第一位为金黄色葡萄球菌,共61株),痰标本分离率最高,主要引起神经外科和重症监护病房患者的下呼吸道感染,其中2005年16株,2006年分离标本17株,2007年分离14株。该菌对美罗培南(碳青霉烯类抗生素)敏感率最高达2005年90.7%,2006年85.2%,2007年80.6%;对哌拉西林/他唑巴坦敏感率为2005年65.1%,2006年45.1%,2007年43.7%,菌株耐药率有逐年上升趋势。结论鲍曼不动杆菌在神经外科重症监护病房常见,对碳青霉烯类抗生素敏感率最高,且耐药性有逐年上升趋势。

Objective To determine the resistance of clinical isolates of Acinetobacter baumannii （Ab） from 1st Hospital of Jilin University. Methods The bacterial suseeptibilikties of antimicrobial agents were determined by automatic microorganism analytical system method using biosMerieumx VITEK2. The results were analyzed with WHONET 5.4 software. Results A total of 47 strains were isolated from 2005 to 2007.The infection rate of Ab in the second place（the 1 st is Staphylococcus aureus,total of 61 strains ）, the isolation rate of Acinetobacter baumannii was 66 % in sputum specimens, and majority of the isolate s caused lower respiratory tract infection in Neurosurgery and NCU inpatients.The susceptible to Meropenem in 2005 is 90.7% ,in 2006 is 85.2% and in 2007 is 80.6% ; the susceptible to piperacillin sodinm/tazobactam sodium in 2005 is 65.1%, in 2006 is 45.1% and in 2007 is 43.7%. Multi-drug resistant strains increased annually. Conclusion The Acinetobacter baumannii is common infected in Neurosurgery and NCU,it＇s sensitive to Carbapenems sodium. The antibiotic resistance rate of Aeinetobacter baumannii isolate s shows a tendency towards increasing.