L-精氨酸对妊娠小白鼠血液生理指标的影响

Effect of L-arginine on Blood Physiological Parameters of Pregnancy Mouse

目的:宫内发育迟缓(IUGR)是影响母畜繁殖力的重要因素之一,试验拟通过研究0.5%精氨酸对孕鼠血液生理指标变化的影响,揭示精氨酸缓解IUGR的部分机理。方法:将20只孕鼠随机分成对照组和试验组,对照组饲喂基础饲料,试验组饲喂基础饲料中添加了0.5%精氨酸的日粮,妊娠15 d采血,EDTA抗凝,用CA500全自动血液分析仪进行血液生理指标分析。结果:试验组孕鼠的白细胞总数、淋巴细胞数量、单核细胞数量、中性粒细胞数量、红细胞总数都显著增加(P<0.05),其他指标未见显著变化。结论:日粮中添加0.5%L-精氨酸会影响孕鼠血液白细胞数量、红细胞数量及血液流变性,从而改善胎盘血液循环及运输氧和营养物质的能力,这可能在缓解胎儿子宫生长受限中具有重要的作用。

Aim： to investigate the effect of L -arginine （Arg） on the changes in blood physiological indexes of pregnant mice to expatiates some mechanism of Arg on Intrauterine growth retardation （1UGR）. Methods： 20 pregnant mice were randomly divided into control group and experimental group, the cantrol group were given basic feed, and the experimental group were fed with diet containing 0. 5% Arg, The blood sample were picked by neck vein after pregnancy 15d, EDTA anticoagulant, then it was measured by CA -500 automatic blood analyzer. Results： The total number of white blood cells （WBC）, lymphocyte, mononuclear cell, neutrophil, red blood ceils （RBC） of pregnancy mice of experimental group were significantly increased （ P 〈 0.05 ）. Conclusion ： the number of WBC, RBC and blood theology may be impacted by dietary containing 0.5 % Arg, thereby improving the placental blood circulation and the capacity of transporting oxygen and nutrients, which may have an important role on alleviating IUGR of mice.