摘要
目的:探讨胰母细胞瘤(pancreatoblastoma,PB)的病理学特征及其鉴别诊断。方法:对1例小儿胰母细胞瘤组织进行光镜和免疫组化标记,观察其病理形态特点,分析其鉴别诊断要点。结果:PB主要由上皮细胞构成。上皮细胞为比较一致的多角形细胞,形成腺泡状、巢状及片状。抗胰糜蛋白酶细胞角蛋白广谱阳性、癌胚抗原阴性、铬粒蛋白A阴性、突触蛋白阴性、甲胎蛋白局灶阳性及CD56阴性。结论:虽然PB是一种罕见的胰腺外分泌恶性肿瘤,但在儿童胰腺肿瘤中最常见。鳞状上皮岛为其组织学特征性改变,在诊断中应与其他胰腺肿瘤鉴别。
Objective:To investigate the morphologic features and differential diagnosis of pancreatoblastoma. Methods:One case of pancreatoblastoma was studied by light microscopy and immunohistochemistry on clinicopathological characteristics. Results:The kid presented an abdominal mass with no symptoms. Microscopic findings showed that mainly composed of epithelial cells, the uniform epithelial cells were polygonal, which formed structures resembling acini, nests and solid islands. Immunohistochemical findings included the tumor cells positive for the CK and AFP, negative for the CEA, CgA,Syn and CD56. Conclusions:Pancreatoblastoma is an extremely rare tumor of the exocrine pancreas, and it is the most common pancreatic neoplasm in children. The present of squamoid nests is characteristics. It should be differentiated from other pancreatic neoplasms.
出处
《蚌埠医学院学报》
CAS
2009年第2期120-122,共3页
Journal of Bengbu Medical College
关键词
胰腺肿瘤
胰母细胞瘤
儿童
住院
pancreatis ncoplasms
pancreatoblastoma
child, hospitalized