线粒体天门冬氨酸氨基转移酶同工酶在肝脏疾病中的临床意义

Study on Clinical Value of Serum Aspartate Aminortransferase in Liver Diseases

目的探讨血清线粒体天门冬氨酸氨基转移酶同工酶(mitochondrial aspartate aminotransferase,m-AST)在不同肝病患者中的变化及其临床意义。方法用日立7170A全自动生化分析仪测定123例不同肝病患者血清m-AST及ALT、AST、AKP、GGT、AFU、5’-NT活性,对结果进行多变量方差分析。结果各组肝病患者m-AST因病情不同而有不同程度的升高。急性肝炎组m-AST明显升高,与正常对照组相比差异具有显著性(P<0.01),肝硬化代偿期,m-AST变化不明显,失代偿期,m-AST持续升高。AST和ALT两种酶在各种肝病时有不同程度升高。AKP、GGT、5’-NT活力主要在肝癌中增高明显。结论m-AST可作为诊断肝脏损伤、坏死及预后判断的敏感指标,特别是在急性肝炎-慢性肝炎-肝硬化-肝癌这条疾病链上能够比较客观地反映疾病所处时期,作为疾病鉴别诊断、指导治疗及预后判断的一项有价值的指标。

Objective To study the changes and the clinical significance of serum mitochondrial aspartate aminotransferase （m - AST） in patients with different liver diseases. Methods The serum m - AST, ALT, AST, AKP, GGT, AFU, and 5＇ - NT of 123 patients with different liver diseases were measured by HITACHI 7170A auto Analyzer. Results In different states of patients, the serum level of m - AST increased in different degrees. The m - AST elevated significantly in acute hepatitis group. In the time of liver cirrhosis commutation, the m - AST change was not significant, but in the time of uncommutation, m- AST increased continuously. The AST and ALT increased in the patients with different liver diseases. AKP, GGT, and 5＇ - NT increased in the patients with hepatocarcinoma. Conclusions As a sensitive index in clinical diagnosis of liver damage, necrosis, and prognosis estimation, m - AST reflects the disease period in the chain of acute hepatitis, chronic hepatitis, hepatocirrhosis, and hepatocarcinoma. Therefore, m- AST is a valuable index in diagnosis disease, treatment guidance, and prognosis estimation.