肺癌患者外周血T细胞亚群的表达及其临床意义

Expression and Its Clinical Significance of T Lymphocyte Subsets in Peripheral Blood of Patients with Lung Carcinoma

目的探讨肺癌患者外周血T细胞亚群的表达及其临床意义。方法应用流式细胞仪检测60例肺癌患者和60例健康者的外周血T细胞亚群的表达情况。结果外周血T细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+表达,肺癌患者与正常人群比较,差异有统计学意义(P<0.001);Ⅰ期、Ⅱ期肺癌患者与Ⅲ期、Ⅳ期肺癌患者比较,差异有统计学意义(P<0.001)。结论肺癌患者外周血T细胞亚群异常,晚期肺癌患者机体免疫下降更为明显。

Objective To explore the expression and clinical significance of T lymphocyte subsets in peripheral blood of patients with lung carcinoma. Methods Venous blood was obtained from 60 patients with lung carcinoma and 60 healthy volunteers. Percentages of T lymphocyte subsets were measured by flow cytometry. Results Compared to the controls, 60 patients with lung carcinoma had significant differences in the percentages of CD3^＋, CD4^ ＋, and CD8 ^＋ T cells and the CD4 ^＋/ CD8^ ＋ ratio（P〈0.001）. There was also significant difference in the percentages of T lymphocyte subsets between earlier carcinoma（stageⅠand Ⅲ ）ant：l advanced carcinoma（stage Ⅲ and Ⅳ）（P〈0.001）. Conclusions Abnormal T lymphocyte subsets exist in the peripheral blood of patients with lung carcinoma, and the immunity of patients with advanced lung carcinoma significantly decreases.