三七总皂苷对老年性痴呆动物模型快速老化小鼠大脑Aβ_(1-40)、Aβ_(1-42)表达的影响

Inhibitive Effects of Panax notoginseng Saponins on Expression of Aβ_(1-40),Aβ_(1-42) Protein in SAMP8′s Brain

目的:探讨三七总皂苷(PNS)对快速老化小鼠SAMP8大脑Aβ1-40、Aβ1-42表达的影响。方法:采用免疫组织化学方法,随机选取快速老化小鼠大脑顶叶皮层、海马周围白质连续五个视野在高倍显微镜下观察,并计数五个视野下Aβ1-40、Aβ1-42免疫阳性细胞的平均个数。结果:PNS能明显减少快速老化小鼠大脑Aβ1-40、Aβ1-42免疫阳性神经元的数量。结论:PNS对SAMP8小鼠大脑Aβ1-40及Aβ1-42的表达有明显的抑制作用。

Objective： To observe inhibitive effects of Panax notoginseng saponins on expression of AAβ1-40,Aβ1-42 protein in SAMPS＇s brain. Methods： Amount of AAβ1-40,Aβ1-42 immuno-positive neurons was detected in parietal cortex and hippocamp in their brains under high power lens（40 x ） by immunohistochemistry analysis. Results： PNS could reduce the amount of AAβ1-40,Aβ1-42 protein in parietal cortex and hippocamp. Conclusion： PNS can reduce the amount of AAβ1-40,Aβ1-42 protein in SAMP8＇s brain.