健康相关行为与肺结核发病的病例对照研究

A case-control study on health related behavior and pulmonary tuberculosis

目的探讨健康相关性行为与肺结核发病的关系,揭示肺结核危险因素。方法采用病例对照设计,应用自行设计的问卷调查济宁市136例肺结核病例和149例对照的健康相关行为及其它肺结核潜在危险因素情况,并进行单因素和多因素条件Logistic回归分析。结果多因素条件Logistic回归分析显示,接种卡介苗(OR=0.168,OR95%CI:0.086～0.327,P=0.000)是肺结核发病的保护性因素,结核病人接触史(OR=2.405,OR95%CI:1.113～5.200,P=0.026)、心理健康程度低(OR=1.983,OR95%CI:1.277～3.080,P=0.002)、吸烟(OR=6.282,OR95%CI:3.188～12.382,P=0.000)和已戒烟(OR=9.938,OR95%CI:2.851～34.634,P=0.000)是肺结核危险因素。结论接种卡介苗能够有效预防肺结核,而接触结核病人、吸烟以及心理健康程度低都是肺结核发病的危险因素。

Objective To analyze the relationship between health-related behavior and pulmonary tuberculosis. Methods A case-control study was conducted.Informations on health -related behavior and other factors associated wihtof tuberculosis were collected in 136 cases and 149 controls using a questionnaire designed by ourselves.Univariate and multivariate non-conditional logistic analyses were conducted in the end. Results Bacille Calmette-Gu6rin （BCG） immunization （OR=0.168,OR 95% CI： 0.086- 0.327,P=0.000）,history of tuberculosis （OR=2.405,OR 95% CI： 1.113- 5.200,P=-0.026）,mental health level（OR=1.983,OR 95% Ch 1.277-3.080,P=-0.002）,Current smoking（OR=6.282,OR 95% CI： 3.188-12.382,P=0.000）and ex-smoking （OR=9.938,OR 95% CI： 2.851-34.634 ,P=0.000 ）were significantly associated with pulmonary tuberculosis in multivariate non-conditional logistic analyses after adjusting other factors. Conclusion Immnization with BCG is effective for prevention of tuberculosis. Exposed to tuberculosis,cigarette smokingan mental health status are the risk factors associated with pulmonary tuberculosis.