奥美拉唑治疗功能性消化不良的临床分析

Clinical analysis on omeprazole in treatment of functional dyspepsia

目的评价小剂量奥美拉唑治疗功能性消化不良(FD)的疗效及安全性。方法将门诊就诊的300例FD患者随机分为两组,口服小剂量奥美拉唑150例(治疗组),10mg,1次/d;口服多潘立酮共150例(对照组)10mg,3次/d。疗程均为4周。观察两组患者食欲不振、胃部烧灼感、餐后饱胀、上腹痛及嗳气等症状改善程度及不良反应。结果两组治疗前后患者食欲不振、胃部烧灼感、餐后饱胀、上腹痛及嗳气等症状前后改善程度差异有统计学意义(P<0.05)。上述症状评分治疗后两组比较,差异均无统计学意义(P>0.05),不良反应发生率差异具有统计学意义(P<0.05)。结论小剂量奥美拉唑治疗FD疗效肯定,多潘立酮联合用药效果相近,但是用药剂量小而且不良反应少,值得临床推广应用。

Objective To evaluate the efficacy and safety of omeprazole in treatment of functional dyspepsia. Methods 300 cases of functional dyspepsia were randomly allocated into 2 groups, The treatment group was treated with omeprazole 10 mg qd, and the control group was treated with domperidone 10 mg tid. The course of treatment in both groups was 4 weeks. The clinical symptoms such as heartburn, postprandial distention, epigastric pain and eructation as well as adverse reactions were observed. Results There was statistical significance in degree of im- provement in clinical symptoms in comparison with pre and post treatment in these two groups （ P 〈 0.05 ）, the difference in scores of above - mentioned clinical symptoms between these two groups after treatment had no statistical significance （ P 〉 0.05 ）, but it was statistically significant in the occurrence of adverse reactions in these two groups, Conclusion The efficacy of omeprazole in treatment of functional dyspepsia is exact, and the efficacy of omeprazole is similar to domperidone, but the dosage of oraeprazole is smaller with less adverse reactions. It is worthy to be recommended for clinical application.