蒙脱石散和自配漱口液交替含漱防治放射性口腔黏膜损伤的临床观察

Clinical prevention and control of radioactive oral mucosa injury by Montmorillonite powder and self gargle mouthwash.

目的观察蒙脱石散和自配漱口液交替含漱对于放射性口腔黏膜损伤的防治作用。方法60例鼻咽癌放疗病人随机分成试验组与对照组各30例,试验组采用蒙脱石散和自配漱口液交替含漱,对照组仅采用自配漱口液含漱。观察两组放射性口腔黏膜损伤的发生情况。结果两组口腔黏膜放射性损伤发生率均为100%。3、4级黏膜损伤发生率试验组为10.0%,对照组为33.3%,两组差异有显著意义(P<0.05)。试验组较对照组口腔黏膜损伤的程度有所减轻,发生时间有所延迟。结论蒙脱石散和自配漱口液交替含漱防治放射性口腔黏膜损伤安全有效,值得临床推广和应用。

Objective To observe the clinical prevention and control of radioactive oral mucosa injury by Montmorillonite powder and self gargle mouthwash. Methods 60 patients with nasopharyngeal carcinoma were randomly divided into experimental group and control group, the patients in experimental group were alternatively applied with Montmorillonite powder and liquid of gargle with mouthwash, and patients in control group were only applied with self gargle for mouthwash. The status of oral mucosa injury was observed in patients of these two groups. Results The rate of oral mucosa injury was 100% in patients of two groups. The incidence rate of 3 and 4 - grade mucosa injury was 10% in patients of experimental group while it was 33.3% in patients of control group. The time for occurrence of oral mucosa injury was delayed in patients of experimental group in comparison with those of control group. Conclusion Montmorillonite powder and gargle with mouthwash are effective and safe in prevention of mucosa injury and it is worthy to be recommended.