膀胱肿瘤患者的凝血象研究

The study of hemocoagulation in patients with bladder tumors

为探讨凝血象在膀胱肿瘤患者中的改变，分别采用全自动血细胞分析法、血凝法和定量酶联免疫吸附法对膀胱肿瘤组凝血象指标，包括血小板（PLT）、血小板平均体积（MPV）、血小板比积（PCT）和血小板平均宽度（PDW）以及凝血酶原时间（PT）、部分凝血活酶时间（APTT）、纤维蛋白原（Fbg）和D－二聚体予以测定，并与非肿瘤组进行比较。结果膀胱肿瘤组PLT较非肿瘤组明显增高（P＜0.01），MPV降低（P＜0.05），PCT较非肿瘤组有极显著性差异（P＜0.01）；而PDW、PT、APTT及Fbg无显著性差异（P＞0．05）；膀胱肿瘤组D－二聚体含量明显高于非肿瘤组（P＜0．01）。认为膀胱肿瘤患者凝血象指标异常，其中以PLT、PCT和D－二聚体改变尤为明显。

The study of hemocoagulation was carrled out in 42 cases of bladder tumor. Theplatelets (PLT) and throbocytodrit (PCT) were significantly increased compared to urinary noncancer patients (P <0.01). Mean platelet volume (MPV) decreased (P <0. 05) and there was nocbange of platelet distribution width (PDW). The prothrombin time (PT) and activated partialthromboplastin time (APTT) and fibrinogen (Fbg) had not been changed as compared with urinary non－cancer patients. In fibrinolysis system,the plasma ixixmer in bladder tumor patients weresignificantly increased. The results suggested that the change of coagulation had a relationship tobladder tumor. D－ixmer can be used as a marker of monitoring urinary tumors.