体外循环对患者T淋巴细胞免疫功能的影响

Damaging effects of cardiopulmonary bypass on human T lymphocytes subsets

目的 :探讨体外循环 ( CPB)对患者 T淋巴细胞免疫功能的影响。方法 :测定实验组 ( 35例CPB心脏手术 )、对照组 ( 10例非 CPB心脏手术 )围术期 T淋巴细胞亚群和白细胞、淋巴细胞计数。进行各时点指标与术前比较的方差分析 ( x± s) ,组间两两比较配对 t检验。结果 :实验组 T淋巴细胞亚群和淋巴细胞计数较术前显著下降 ,自停 CPB持续至术后 3天。白细胞计数在术后 3～ 8天显著高于术前水平 ( P<0 .0 1,P<0 .0 5)。结论 :CPB可损害患者 T淋巴细胞免疫功能 ,使术后机体抵抗力下降 ,易并发感染 。

Objective:To study the damaging effects of cardiopulmonary bypass (CPB) on human im mune func- tion.Methods:T lymphocytes subsets targets including CD+ 3 、CD+ 4 、CD+ 8、CD+ 2 0 、CD+ 5 7、IY and WBC levels of peripheral blood from patients of cardiac surgery with CPB(n=35 ) and without CPB (n=10 ) during specially designated periopera- tive time were measured.All data of the two groups were processed statistically(x± s) .Results:All targets except WBC were statistically lower than those before operation durim g shortly postoperative period(from the conclussion of CPB to 3 postoperative days) in patients of cardiac surgery with CPB.The target of WBC was statistically higher than that before operation during 3 to 8postoperative days (P<0 .0 1,P<0 .0 5 ) .Conclusions:No- pulsatile blood stream, gas- blood boundary and artifical conduitsystem of CPB can break visible composition of blood and severely affecthuman immune system.Attention should be paid to prevent infection during postoperative period.