肝素防治增生性玻璃性视网膜病变的实验研究

Expermental study the prevention of Heparin on proliferative vitreoretionopahy

本研究旨在探讨肝素对实验性增生性玻璃体视网膜病变PVR的疗效及毒性。用新鲜兔自血0．1ml注入玻璃体腔内造成PVR模型。用兔眼玻璃体内注射药物的方法观察肝素对限内纤维增生的抑制作用及肝素的毒性。结果表明：肝素对防治增生性玻璃体现网膜病变有效，玻璃体内注射肝素100IU和50IU对眼部无毒性。本研究为肝素应用于临床提供了依据。

The purpose of this study is to investigate teh efficacy and toxicity of heparin for the treatment of experimental PVR. A PVR model has been made by the injection of 0. 1ml fresh unxoagulated autologous blood in to vitreous cavity of rabbit The inhibition and toxicity of heparin to the intraocular proliferation was observe d The result demonstrate the use of heparin effectively prevent the development of PVR Heparin 100IU and heparin 50IU intravitreal injection had on toxic effect The result may provide a basis for the use of heparin in clinical