摘要
目的探讨原发性高血压患者胰岛素受体在胰岛素抵抗发病中的作用。方法用改良Ｇａｍｂｈｉｒ法测定４８例原发性高血压患者的红细胞胰岛素受体（ＥＩＲ）数目。以空腹胰岛素与血糖浓度乘积的倒数，作为胰岛素敏感指数（ＩＳＩ）。用多元直线回归和相关法，分析ＥＩＲ数目与ＩＳＩ的联系。结果ＥＩＲ的数目与ＩＳＩ直线相关，复合相关系数为０．６４９８（Ｐ＜０．０１）。结论胰岛素受体数目减少是原发性高血压胰岛素抵抗的重要病因。
Objective To assess the role of insulin receptors in the pathophysisology of insulin resistance in essential hypertensive patients.Method\ The numbers of erythrocyte insulin receptors(EIRs) of 48 essential hypertensive patients were measured by a modified Gambhir method.Insulin sensitive index(ISI) was the reciprocal of fasting serum insulin and serum glucose product.Multiple linear regression analysis and correlation analysis was explored to investigate the relationship between EIRs and ISI.Results\ There were linear correlation between ISI and the numbers of two type EIRs.The coefficient of multiple correlation was 0.6498(P<0.01).Conclusions\ Deminishing of insulin receptors may play an important role in etiology of insulin resistance.
出处
《现代诊断与治疗》
CAS
1998年第1期15-16,共2页
Modern Diagnosis and Treatment
关键词
胰岛素抵抗
胰岛素受体
原发性
高血压
Insulin resistance Insulin receptor Essential hypertension
