甲亢女性患者突眼症状与淋巴细胞微核率的关系

Relationship between the Ophthalmoptosis Symptom and Micronucleus Ratio in the Lymphocytes of Female Patients with Hyperthyroidism

目的探讨甲亢患者突眼症状与遗传、环境因素的关系。方法对甲亢突眼病例组、无突眼病例组和对照组（每组３０名女性）的淋巴细胞微核进行检测。结果各组的微核率依次为４．２３±２．２５％、２．０５±１．５％和０．９７±０．７４％。甲亢突眼组的微核率与无突眼组相比较有显著差异（Ｐ＜０．０１），同时，两组的微核率明显高于对照组（Ｐ＜０．０１）。结论甲亢患者有疾病易感倾向，而且，患者的病情与微核率均表现出多因素的累加效应。

Objective To research the hereditary and enviroment factor associated with the ophthalmoptosis symptoms in hyperthyroidism.Method Micronucleus test was assayed in peripheral blood lymphocytes of the female patients with hyperthyroidism(30 cases with ophthalmoptosis group and 30 cases without ophthalmoptosis group).Another 30 healthy females were referred as control.Results It showed that the micronucleus ratio was respectively 4.23±2.25%,2.05±1.5% and 0. 97±0.74%. The micronucleus ratio of group with ophthalmoptosis was significantly higher than that of group without ophthalmoptosis(P<0. 01),and the micronucleus ratio of the both groups was also higher than that of control group(P<0.01). Conclusion\ It indicated that the patients had a predisposition of the disease,and it also showed the additive effect of polygene in symptoms of hyperthyroidism and micronucleus ratio.