肝动脉化疗栓塞后残留肝癌细胞的P-糖蛋白表达

Expression of P-glycoprotein in residual liver cells of hepatocellular carcinoma after transcatheter arterial chemoembolization

目的研究肝动脉化疗栓塞(TACE)后残留肝细胞癌(HCC)的多药耐药性(MDR)。方法采用免疫组化的方法,检测33例TACE治疗后残留HCC(TACE组)和42例未经任何形式化疗的HCC(对照组)的P-糖蛋白(PGP)表达。结果 TACE组的PGP表达阳性率为84.85%,显著高于对照组的54.76%(P<0.01)。结论 HCC存在内源性MDR,TACE治疗又进一步诱导其产生获得性MDR;TACE后残留HCC的这种高度耐药性可能是其赖以生存的机制之一。

Objectives To investigate the multidrug resistance (MDR) of residual hepatocellular carcinoma (HCC) following the treatment of transcatheter arterial chemoembolization (TACE). Methods By the method of immunohistochemstry the expression of P-glycoprotein (PGP), the multidrug resistance gene product, was detected in 33 HCCs with residual living tumor cells after TACE(TACE group) and, as a control group, in 42 cases of HCC without being previously exposured to any anticancer drug. Results The positive rate of anti-PGP immunostaining was found to be significantly higher in TALE group of HCCs than that in the control group of HCCs(84.85% vs 54.76%; P<0.01). Conclusion The results indicate that, in addition to the originally intrinsic MDR,the residual living HCC cells following TACE de- veloped acquired MDR, which may be one of the mechanisms by which the residual tumor cells survive.