二维康口服液对大鼠实验性肝癌的防治作用

Prevention and treatment of experimental hepatocellular carcinoma with Er-Wei-Kang peroral solution

目的研究二维康口服液(刺五加及黄芪)对大鼠实验性肝癌的防治作用。方法用HE染色法及常规电镜标本制备方法观察肝脏组织学变化及超微结构变化;免疫学检测指标包括自然杀伤(NK)细胞活性,白细胞介素2(IL-2)及肿瘤坏死因子(TNF)含量。结果致癌剂加用中药组较单纯致癌剂组癌结节形成少且小,癌周组织细胞核及胞浆细胞器基本保持完整,NK活性及IL-2活性单位显著升高(P<0.01)。结论二维康口服液能够阻止肝癌的发生,发展。

Objective To study the prevention and treatment of experimental hepatocellular carcinoma in rats with Er-Wei-Kang peroral solution. Methods The contents of IL-2, TNF and NK activities as immuno- logical indicators were measured. The histological and ultrastructural changes in liver tissue were ob- served by HE staining and under microscope. Results In the group receiving oncogenic drug with Er- Wei-Kang peroral solution the formation of cancer modes was fewer and smaller, the ultrastructure of nucleus and organelle had no obvious changes, and the activities of NK and IL-2 content were increased significantly (P<0.01), as compared with those in the group given oncogenic drug alone. Conclusion Er-Wei-Kang peroral solution could protect hepatocelluar carcinoma from development and growth.