胃癌患者脾细胞免疫功能的研究

Study on spienic cell-mediated immunity of the patients with advanced gastric cancer

目的探讨胃癌患者脾脏的细胞免疫功能。方法检测进展期胃癌患者脾静脉血淋巴细胞(SVL)和脾细胞(SC)的自然杀伤细胞(NK),LAK细胞的杀伤活性及T细胞亚群(TC)与胃良性病变的SVL及外伤性脾破裂SC的对照比较。结果胃癌患者脾脏NK、LAK细胞杀伤活性显著降低(P<0.02,P<0.01);CD_4减少CD_8增加,CD_4 /CD_8比值显著降低(P<0.02～0.01)。结论进展期胃癌患者脾脏免疫功能极度低下。一旦具有合理的指征,联合脾切除对患者的细胞免疫功能不会造成明显不利的影响。

Objective Splenic cell-mediated immuity of the patients with advanced gastric cancer were (AGC) studied. Methods NK and LAK actirvities and T cell subsets in splenic cells (SC) and splenic venous lymphocytes (SVL) from the patients with AGC were measured. Meanwhile, the benign gastric disease (BGD) group, traumatic spleen rupture group and normal group were compared. Results NK and LAK activities of SC and SVL from AGC were markedly decreased (P<0.02, P<0.01); a decrease of CD_4; an incrtase of CD_8 and a decrease of CD_4/CD_8 were noted (P<0.02,P<0.01). Conclusion It indi- cated that splenic cell-mediated immune funtion of AGE pationts were significantly inhibited