原发性乳腺癌组织中bcl-2基因表达与临床病理联系

The expression of bcl-2 in breast carcinomas and its relation to the clinical pathology

目的探讨原发性乳腺癌组织中bcl-2基因的表达与临床病理的关系。方法应用免疫组织化学方法(S-P)研究63例乳腺癌组织,15例癌旁正常乳腺组织中的bcl-2基因表达率、表达特点及与乳腺癌临床病理的联系。结果乳腺癌bcl-2阳性率(49.2%)明显高于癌旁正常乳腺组织的阳性率(20%), P<0.05。乳腺癌组织学分级越高,bcl-2阳性率越高,P<0.05。三年无复发无转移病例阳性率小于三年内有复发转移病列的阳性率,P<0.05。结论 bcl-2基因可能通过调节肿瘤细胞的凋亡而影响乳腺肿瘤组织的生物学行为。

Objectives To study the expression of bcl-2 oncogene products in breast carcinomas and its relation to clinical pathology. Methods Using immunohistochemical method, the expression rate and expression features of bcl-2 oncogene products in carcinomas breast tissue of 63 cases and normal breast tissue of 15 cases of breast carcinomas and their relation to the clinical pathology were investigated. Results The positive rate of 49.2% of bcl-2 in 63 cases of breast carcinomas was obviously higher than that in normal breast tissue (20%, P<0.05). The positive rate of bcl-2 in 9 cases of recurrence and (or) metastasis was higher than that in 54 cases without recurrence and (or) metastasis during 3 years (P<0.05). Conclusion bcl-2 oncogene might be involved in the biological behaviors by regulating the apoptosis of breast cancer cells.