摘要
目的:研究红景天苷对大鼠血液流变学指标、大鼠血小板聚集率、小鼠凝血时间和血小板数的影响。方法:用高分子右旋糖酐制备大鼠急性血瘀模型,观察其对血液流变学指标的影响;给予红景天苷5 d,观察其对大鼠血小板聚集率、小鼠凝血时间和血小板数的影响。结果:红景天苷(6,12,24 mg.kg-1)能有效预防急性血瘀模型大鼠全血黏度(高,中,低切变率)、血浆黏度、红细胞压积以及纤维蛋白原含量的升高;红景天苷各剂量组能降低大鼠血小板聚集率;红景天苷48.0,24.0 mg.kg-1能明显延长小鼠的凝血时间,各剂量组对血小板数无明显影响。结论:红景天苷能显著改善急性血瘀模型大鼠的血液流变学指标,并有一定的抗凝血作用。
Objective：To investigate the effects of salidroside on hemorheology of rats, platelet aggregation rate in vitro in rats, coagulation time （CT） and platelet count （PC） in mice. Methods： The model of acute blood stasis was established with high-molecular weight dextran, the parameters were tested, such as blood viscosity, fibrinogen and hematocrit （Hct） etc; the effects of salidroside on platelet aggregation rate of rats, CT and PC of mice were rest after pretreatment with salidroside for 5 days. Results： Salidroside （6, 12, 24 mg· kg^-1） could effectively prevent the ascending of whole blood viscosity, plasma viscosity, fibrinogen and Hct in the acute blood stasis model. Salidroside at all doses could effectively decrease platelet aggregation rate; Salidroside （48 .0, 24.0 mg·kg^-1） could prolong CT and has no effect on PC. Conclusion： The results suggest that salidroside improves the hemorheological parameters of rats with acute blood stasis, and salidroside has some effects on anticoagulation, while it has no effect on PC.
出处
《中国实验方剂学杂志》
CAS
北大核心
2009年第2期51-54,共4页
Chinese Journal of Experimental Traditional Medical Formulae
