摘要
目的:观察芝麻素对高脂血症大鼠血脂及脂肪肝形成的影响。方法:建立高血脂大鼠模型。予不同剂量芝麻素灌胃治疗8周后,检测大鼠血脂、脂蛋白代谢酶、脂质过氧化物、载脂蛋白及肝指数、肝脏病理变化。结果:芝麻素能显著降低模型组大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B100(ApoB100)、丙二醛(MDA)含量和肝指数,升高高密度脂蛋白胆固醇(HDL-C)、超氧化物歧化酶(SOD)、肝酯酶(HL)活性(P<0.05);并使脂肪肝损伤得到明显改善。结论:芝麻素具有调脂和防治脂肪肝的作用,可能与调节脂质代谢及抗氧化作用等有关。
Objective： To investigate the effects of sesamin on lipidemia and the formation of non-alcoholic steatohepatitis（NASH）. Methods： Hyperlipidemia rats model were established by feeding high lipid diet. The liver index, total cholesterol （ TC）, triglyeeride （ TG）, high density lipoprotein-cholesterol （ HDL-C）, low density lipoproteincholesterol（ LDL-C）, lipoprotein lipase （LPL）, hepatic lipase （ HL）, apoproteinA1 （ ApoA1 ）, apoproteinB100 （ ApoB100）, superoxidedismutase （SOD）and malonaldehyde （MDA） were measured after administration with sesamin for 8 weeks. As well as, livers were taken for histopathological examination. Results： Therapeutic groups were significantly decreased TC, TG,LDL-C, ApoB100, MDA and liver index, increased HDL-C, HL, SOD（ P 〈 0.05）. The fatty degeneration and steatosis in liver were ameliorated by sesamin. Conclusion： Sesamin can remarkably modulate lipidemia and cure the NASH. Its mechanism is probably mediated through regulating lipids metabolism and anti-oxidation.
出处
《中国实验方剂学杂志》
CAS
北大核心
2009年第2期55-58,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
安徽省教育厅自然科学研究基金重点项目(2006KJ099A)
关键词
芝麻素
高脂血症
大鼠
脂肪肝
病理学检查
sesamin
hyperlipidemia
rat
nonalcoholic steatohepatitis
histopathological examination
