肝硬变兔肉毒碱变化及对中、长链脂肪乳剂代谢的影响

Effects of the carnitine alteration on the metabolism of medium- and long-chain triglyceride in the cirrhotic rabbits

目的探讨肝硬变家兔体内肉毒碱变化及对中、长链脂肪乳剂代谢的影响。方法 21只新西兰家免经结扎胆总管制成肝硬变模型,随机分两组,肠外营养(PN)-LCT组及PN-MCT组,两组所含非蛋白热卡及氮量均相等。结果肝硬变时血中甘油三酯、肉毒碱(CNT)的含量均明显升高(P<0.01),在PN7天,LCT组甘油三酯、CNT均高于MCT组(P<0.01);各组织肝脏、心肌、骨骼肌及小肠中CNT含量明显下降(P<0.01);肝内脂肪含量LCT组高于MCT组(P<0.01)。结论 MCT/LCT乳剂可能是应用于肝硬变时更为理想的能源。

To study the effects of the carnitine alteration on the metabolism of medium-and long- hain triglyceride in the cirrhotic rabbits. Methods Twenty-one rabbits with liver cirrhosis induced by ligating common bile duct were divided into two groups. LCT-PN and MCT-PN group, which contained same non-protein energy and nitrogen. Results Serum TG. Chol and carnitine in cirrhosis were high- er than those in control group. Seven days after PN, serum TG. carnitine in LCT group were higher than iii MCT/LCT group. Tissue carnitine in liver, heart, muscle and intestine were lower than in control group. Conclusions MCT/ICT emulsion is less dependence of the carnitine to quickly turnover the clearance of exogenous fat and less fat store. MCT/LCT is a suitable source of energy for cirrhosis.