中药联合米非司酮治疗异位妊娠临床疗效观察

Clinical Observation on Mifepristone Combined with Chinese Herbs in Treating Ectopic Pregnancy

目的观察中药联合米非司酮治疗异位妊娠的临床疗效。方法将95例异位妊娠患者随机分为3组:治疗组33例口服米非司酮200 mg/d,连续3 d,并加服自拟宫外孕2号方;对照1组30例给予甲氨蝶呤50 mg/m^2单次肌肉注射;对照2组32例口服米非司酮200 mg/d,连续3 d。监测血β-HCG水平及包块变化情况,记录β-HCG降至正常和包块消失所需时间。结果治疗组治疗成功率为84.85%,与对照1组的83.33%比较差异无统计学意义(P>0.05),而与对照2组的62.50%比较差异有统计学意义(P<0.05)。治疗组β-HCG复常时间与对照1组差异无统计学意义,但短于对照2组(P<0.05);治疗组包块消失时间少于两对照组(P<0.05),且不良反应少于对照1组。结论米非司酮联合中药疗效与甲氨蝶呤相当,但不良反应较少。

Objective To explore the clinical effects of mifepristone combined with Chinese herbs in the treatment of ectopic pregnancy. Methods Ninety-five subjects were randomized into three groups ： group A in which 33 cases were treated with mifepristone ＆ ＂Gongwaiyun Decoction II＂ , group B in which 30 cases were treated by intramuscular injection of MTX, and group C in which 32 cases were treated with mifepristone. The time of β-HCG reducing to normal and masses disap-pearance was observed. Results The effective rate was 84.85% in group A, similar to 83.33% in group B （ P 〉 0.05 ） , higher than 62.50% in group C（P 〈 O. 05 ） ; the time of β-HCG reducing to normal in group A is similar to group B, but shorter than group C （ P 〈 0.05 ） ; the time of masses disappearance in group A was shorter than groups B and C, with fewer side effects. Conclusion Mifepristone ＆ Chinese herbs act the same as MTX in the treatment of ectopie pregnancy, but with fewer side effects.