妊高征患者血清HSP70水平的表达及意义

Expression and significance of serum HSP70 in patients with severe pregnancy-induced hypertension syndrome

目的:探讨血清HSP70在妊高征中的价值。方法:用双抗体夹心ELISA法检测妊高征患者和正常妊娠组血清HSP70的水平并进行比较。结果:非孕对照组与正常妊娠组比较无差异(P>0.05),轻、中、重组妊高征患者血清HSP70含量均明显高于同孕龄对照组和非孕对照组(P<0.01),轻度妊高征组与同孕龄组比较有差异(P<0.05),中度与重度妊高征组则明显高于轻度妊高征组(P<0.01),且中、重度间有显著性差异(P<0.01)。表中显示,随妊高征程度加重血清热休克蛋白70含量越高。结论:血清HSP70含量在妊高征的早期和衡量疾病严重程度方面,具有重要的临床价值。

Objective ：To find the value of serum HSPT0 in the severe pregnancy-induced hypertension syndrome. Methods： A comparison is made in the level of serum HSPT0 between the group of patients with severe pregnancy - induced hypertension syndrome and the normal group with the double -antibody solid -phase technique ELISA. Results：No difference has been found in both non - pregnant group and normal gestation group （ P 〉 0. 05 ）. The contents of serum HSF70 protein of light, medium and severe groups with the pregnancy - induced hypertension syndrome are much higher than that of the control group of the same gesrational age and the non- pregnant group（ P 〈 0. 01 ）. A difference has been found between the group with light pregnancy -induced hypertension syndrome and the group of the same gestational age（P 〈0. 05 ）. The contents of serum HSPT0 protein of the medium and severe groups are much higher than that of the light group （ P 〈 0. 01 ）. Further more, an apparent distinctness has been found between the medium group and the severe group （P 〈 0. 01 ）. As the table shows, the severer the pregnancy - induced hypertension syndrome is, the higher the content of serum heat shock protein rises. Conclusion ： It is of great clinical value in diagnosing the severity of the pregnancy - induced hypertension syndrome to test the content of serum HSP70.