HSP27和Survivin在宫颈癌中的表达及其意义

Expression and significance of HSP27 and survivin in uterine cervical carcinomas

目的:研究HSP27和Survivin在宫颈癌组织中的表达及其意义,以探讨宫颈癌的发生机制。方法:采用免疫组织化学方法对50例宫颈癌石蜡标本、宫颈上皮内瘤样病变CINⅠ20例、CINⅡ-Ⅲ20例、正常宫颈组织20例进行HSP27和Survivin的检测。结果:在宫颈癌组织中HSP27和Survivin的阳性率高于CIN和正常宫颈组织(均P<0.05),HSP27和Survivin阳性表达率与病理分级和淋巴转移有关(均P<0.05),HSP27阳性表达率均与临床分期有关(P<0.05),HSP27的阳性表达率与年龄分组无关(P>0.05),Survivin的阳性表达率与年龄分组和临床分期无关(均P>0.05)。结论:宫颈上皮内瘤样病变及宫颈癌组织中HSP27和Survivin表达的异常表达影响CIN的发展及宫颈癌的发生。

Objective： To investigate expression and significance of HSP27 and survivin in uterine cervical carcinomas. Methods ： Formalin - fixed, paraffin - embedded samples including 50 cases of squamous cell carcinomas, 20 cases of cervical intraepithelial neoplasia CIN Ⅱ-Ⅲ and 20 cases of CIN 1 and 20 cases of normal cervical tissues were studied. Using Polymer immunohisto - chemical technique, the authors examined the expression of HSP27 and Survivin in these samples. Results： There were significant differences for HSP27 and Survivin between carcinomas, CIN and normal cervical, respectively （ all P 〈 0. 05 ）. Expression of HSP27 and Survivin were correlated with tumor grades, lymphnode metastasis （ all P 〈 0. 05）. Expression of HSP27 was correlated with clinical stages （ P 〈 0. 05 ）. Expression of HSP27 was not correlated with age in uterine cervical Carcinomas（ P 〉 0. 05 ）. Expression of Survivin was not correlated with age and clinical stages in uterine cervical Carcinomas （ P 〉 0.05 ）. Conclusion：The tissues of CIN and cervical carcinomas changes in HSP27 and Survivin expression, which can influent the progression of CIN and carcinogenesis of cervical carcinomas.