组织模型偏振散射光谱特性研究

A Research on Polarized Scattering Spectra Properties for Tissue Phantom

结合偏振门技术和米氏散射理论,建立了组织模型的偏振散射差分光谱理论模型。计算分析了粒子群的平均尺寸、相对折射率变化时后向偏振散射差分光谱的特征。结果表明,利用偏振门技术测量的差分光谱主要是来自表层粒子的光信号,偏振散射差分光谱对粒子平均尺寸及相对折射率的变化比较敏感,随着粒子平均尺寸的增加,光谱振荡频率将增加,而随着相对折射率的减小,光谱的振幅减小,且差分光强值减小。该方法对于早期癌症检测具有潜在应用意义。

Theoretical model of polarized Cscattering differential spectrum based on polarization gate technology and Mie scattering theory is established for tissue phantom, thereafter, the properties of polarized backscattering spectra are analyzed by simulation calculation when the mean diameter and relative refractive index of particles change. The results show that light from surface layer particles mostly contribute to the differential spectrum measured by polarization gate technology, the spectrum can reflect the change of diameter and relative refractive index sensitively, with the increase of the size of particles, the oscillation frequency of spectra will increase. When the relative refractive index is decreased in limited range, the amplitude of oscillation spectra and differential signal intensity are also weakened. It implies the polarized scattering differential spectrum can be used for pre-cancer detection potentially.