反复呼吸道感染患儿免疫球蛋白及IgG亚类的水平

The Levels of Immunoglobulin and IgG Subclasses in Serum of Children with Recurrent Respiratory Tract Infection

目的:探讨反复呼吸道感染(RRTI)与免疫球蛋白、IgG亚类的关系,为治疗RRTI提供理论依据。方法:采用免疫散射比浊法,检测28例RRTI患儿IgG、IgA、IgM及IgG亚类水平并与对照组比较。结果:RRTI患儿血清IgG、IgA水平与对照组相比差异无显著性,血清IgM水平与对照组相比明显降低(t=-2.524,P<0.05);RRTI组血清IgG2和IgG4水平比对照组明显降低(t=-2.107,-2.72;P<0.05或P<0.01)。结论:RRTI患儿存在一定程度的免疫功能紊乱,检测血清总免疫球蛋白和IgG亚类可提高RRTI的诊断率。

Objective： To explore the relation of recurrent respiratory tract infection （RRTI） with serum levels of immunoglobulin and IgG subclasses, and to provide theorical basis for RRTI treatment. Methods： Serum levels of IgG, IgA, IgM and IgG subclasses of 28 RRTI （18 males and 10 females ） children and 15 normal children （5 males and 10 females） were determined with immuno-scattered turbidity method, and the data were analyzed. Results ： There was no significant difference of levels of IgG and IgA between RRTI group and control group （ P 〉 0.05 ） ; Serum level of IgM of RRTI group was significantly lower than that of control group （P 〈 0.05） ; Serum levels of IgG2 and IgG4 in RRTI group were significantly lower than those of control group（P 〈 0. 05, P 〈 0.01 ）. Conclusion： there is immune disorder to some degree in children with RRTI. To detect serum levels of immunoglobulin and IgG subclasses in children with RRTI could increase correct diagnosis rate.