唾液变形链球菌浓度与年轻恒牙患龋的相关性研究

Correlation between Streptococcus mutans level in saliva and caries status in children

目的探讨唾液变形链球菌浓度在11至12岁小学生中的分布情况及其与患龋状况间的相关性。方法检查365名11至12岁小学生年轻恒牙的患龋情况并收集唾液标本，用单克隆抗体法测量唾液中变形链球菌的浓度。结果随着唾液中变形链球菌浓度的升高，所对应的人数不断减少。患龋儿童的唾液变形链球菌浓度[5．53（1．50，18．00）×10^7个／L]显著高于无龋儿童[3．42（1．60，8．10）×10^7个/L]（P=0．002）。唾液变形链球菌浓度与龋、失、补指数的Spearman相关系数为0．136（P=0．010）。当唾液变形链球菌的浓度达到8．64×10^7个／L时，受检儿童中龋齿检出率会出现成倍的增长。结论唾液变形链球菌浓度在受检儿童中呈偏态分布，其与患龋状况间存在显著的正相关关系，这在龋风险评价中有积极的意义。

Objective To investigate the distribution pattern of salivary Streptococcus mutans （Sin） level in children and its association with caries status. Methods Three hundred and sixty-five 11-12-yearold children participated in this study. Scores of decayed, missing or filled teeth （DMFT） for the permanent dentition were recorded. Salivary Sm concentrations were determined by species-specific monoclonal antibodies. Results Caries-affected children harbored more Sm in saliva [5.53（1.50,18.00）×10^7/L] than their caries-free counterparts [3. 42（1.60,8. 10） ×10^7/L] （P =0. 002）. Salivary Sm concentration tended to rise with the increase of DMFT score. Spearman＇s correlation coefficient for Sm concentration was 0. 136 （P =0. 010）. When salivary Sm concentration reached 8.64 ×10^7/L, children＇s caries experience doubled. Conclusions Salivary Sm level has a skewed distribution among the children studied and associates positively with caries presence. Determination of salivary Sm levels could be used to predict children＇s caries status.