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Olig家族调控脑白质损伤后神经修复的研究进展 被引量：6

Development of Olig family regulating nerve repair after cerebral white matter injury
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摘要 少突胶质细胞是中枢神经系统（central nervous system．CNS）的髓鞘形成细胞．它们能易化神经传导，对神经功能有支持作用。与神经元类似，少突胶质细胞对于损伤，如缺血、缺氧和营养物质的缺乏等也高度敏感．导致髓鞘的脱失和变性。碱性-螺旋-环-螺旋（basichelix—loop—helix,bHLH）转录因子Oligl和Olig2主要表达于少突胶质细胞及其前体细胞，并在少突胶质细胞的产生和分化中发挥了很重要的作用。
作者 赵红 高晓玉 王得新 张拥波
机构地区 首都医科大学附属北京友谊医院神经内科
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2009年第2期201-203,共3页 Chinese Journal of Neuromedicine
基金 国家自然科学基金（30570626）
关键词 少突胶质细胞 Olig1/2 脑白质损伤 髓鞘修复 Olidogendrocyte Oligl/2 Cerebral white matter injury Remyelination
分类号 R686 [医药卫生—骨科学]
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参考文献24

  • 1高晓玉,张拥波,王得新.Olig家族研究进展及其与白质损伤的关系[J].国际神经病学神经外科学杂志,2007,34(3):266-269. 被引量：2
  • 2Xu J, He L, Ahmed SH, et al. Oxygen-glucose deprivation induces inducible nitric oxide synthase and nitrotyrosine expression in cerebral endothelial cells[J]. Stroke, 2000, 31(7): 1744-1751.
  • 3Back SA, Han BH, Luo NL, et al. Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia [J]. J Neurosci, 2002, 22(2): 455-463.
  • 4Matute C. Oligodendrocyte NMDA receptors: a novel therapeutic target[J]. Trends Mol Med, 2006, 12(7): 289-292.
  • 5Levine JM, Reynolds R, Fawcett JW. The oligodendrocyte precursor cell in health and disease[J]. Trends Neurosci, 2001, 24(1): 39-47.
  • 6Tanaka K, Nogawa S, Suzuki S, et al. Upregulation ofoligodendrocyte progenitor cells associated with restoration of mature oligodendrocytes and myelination in peri-infarct area in the rat brain[J]. Brain Res, 2003, 989(2): 172-179.
  • 7Franklin RJ. Why does remyelination fail in multiple sclerosis? [J]. Nat Rev Neurosci, 2002, 3(9): 705-714.
  • 8Ross SE, Greenberg ME, Stiles CD. Basic helix-loop-helix factors in cortical development[J]. Neuron, 2003, 39(1): 13-25.
  • 9Zhou Q, Wang S, Anderson DJ. Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors[J]. Neuron, 2000, 25(2): 331-343.
  • 10Lu QR, Yuk D, Alberta JA, et al. Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system [J]. Neuron, 2000, 25 (2): 317-329.

二级参考文献25

  • 1Zhou Q,Wang S,Anderson DJ.Identification of a novel family of Oligodendrocyte ineage-specific basic helix-loop-helix transcription factors.Neuron,2000,25 (2):331-343.
  • 2Lu QR,Yuk D,Alberta JA,et al.Sonic hedgehog-regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system.Neuron,2000,25(2):317-29.
  • 3Ledent V,Paquet O,Vervoort M.Phylogenetic analysis of the human basic helix-loop-helix proteins.Genome Biol,2002,3(6):1218.
  • 4Liu Y,Rao MS.Olig Genes Are Expressed in a Heterogeneous Population of Precursor Cells in the Developing Spinal Cord.Glia,2004,45(1):67-74.
  • 5Mizuguchi R,Sugimori M,Takebayashi H,et al.Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons.Neuron,2001,31 (5):757-771.
  • 6Park HC,Mehta A,Richardson JS,et al.Olig2 is required for zebrafish primary motor neuron and oligodendrocyte development.Dev Biol,2002,248(2):356-368.
  • 7Rowitch DH,Lu QR,Kessaris N,et al.An'oligarchy' rules neural development.Trends Neurosci,2002,25 (8):417-422.
  • 8Olivier C,Cobos-Silleros I,Perez-Villegas EM,et al.Monofocal origin of telencephalic oligodendrocytes in the chick embryo:the entopeduncular area.Development,2001,128(10):1757-1769.
  • 9Lu QR,Cai L,Rowitch D,et al.Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex.Nat Neurosci,2001,4(10):973-974.
  • 10Zhou Q,Anderson DJ.The bHLH transcription factors Olig2 and Olig1 couple neuronal and glial subtype specification.Cell,2002,109(1):61-73.

共引文献1

同被引文献42

  • 1武辉,方艳秋,王东轩,谭岩.妥泰对围产期缺氧缺血性脑损伤Wistar大鼠海马少突胶质细胞的影响[J].中风与神经疾病杂志,2006,23(4):406-408. 被引量：3
  • 2Masumura M, Hata R, Nagai Y, et al. Oligodendroglial cell death with DNA fragmentation in the white matter under chronic cerebral hypoperfusion: comparison between normotensive and spontaneously hypertensive rats[J]. Neurosci Res, 2001, 39(4): 401-412.
  • 3Kurumatani T, Kudo T, Ikura Y, et al. White matter changes in the gerbil brain under chronic cerebral hypoperfusion[J]. Stroke, 1998, 29(5): 1058-1062.
  • 4den HT, Launer LJ, de Groot JC, et al. Serum carotenoids and cerebral white matter lesions: the Rotterdam scan study[J]. J Am Geriatr Soc, 2001, 49(5): 642-646.
  • 5Schmidt R, Schmidt H, Fazekas F, et al. MRI cerebral white matter lesions and paraoxonase PON1 polymorphisms: three-year follow-up of the austrian stroke prevention study [J]. Arterioscler Thromb Vasc Biol, 2000, 20(7): 1811-1816.
  • 6Juurlink BH, Thorbume SK, Hertz L. Peroxide-scavenging deficit underlies oligodendrocyte susceptibility to oxidative stress[J]. Glia, 1998, 22(4): 371-378.
  • 7Ni J, Ohta H, Matsumoto K, et al. Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats [J]. Brain Res, 1994,653(1-2): 231-236.
  • 8Liu J, Wang X, Shigenaga MK, et al. Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats[J]. FASEB J, 1996, 10(13): 1532-1538.
  • 9Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes [J]. Free Radic Biol Med, 1991, 11(1): 81-128.
  • 10Toyoda T, Lee KS. Differential induction of superoxide dismutase in core and penumbra regions after transient focal ischemia in the rat neocortex[J]. Neurosci Lett, 1997, 235(1-2): 29-32.

引证文献6

二级引证文献14

中华神经医学杂志
2009年 第2期

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