白藜芦醇对急性胰腺炎治疗作用的研究现状与展望

The present status and prospects of resveratrol for its therapeutic effects on acute pancreatitis

关于急性胰腺炎(acute pancreatitis,AP)发病机制的研究,一直是国内外学者探讨的热点。对于AP发病的机制,目前主要有胰酶自身消化学说、微循环障碍学说、炎症因子与细胞介质学说、细胞内钙超载学说、肠道细菌易位与"二次打击"学说、氧化应激与NO作用学说等。白藜芦醇因具有抗炎、抗氧化、抑制血小板凝集、改善微循环等药理作用而受到临床工作者的广泛关注,是一种具有良好应用前景的天然药物。近年来,本课题就白藜芦醇对重症急性胰腺炎的治疗作用进行了大量深入的研究并做了系统的文献分析,认为白藜芦醇可以从多个环节发挥作用,从而起到缓解AP造成的胰腺损害及由此引发的多器官功能损伤。

The pathogenesis of acute pancreatitis （AP） has been a hot issue around the world. Regarding the pathogenesis of AP, there are mainly the trypsin autodigest doctrine, microcirculation theory, inflammation and cell-medium, theory, theory of intracellular calcium overload, bacterial translocation and the ＂two-hit＂ theory, oxidative stress and doctrine of NO role, and so on. Resveratrol, a natural plant extraction with a wide therapeutic effect of anti-inflammation and anti-oxidation, inhibits platelet aggregation, improves microcirculation and has other pharmacological effects. In recent years, we have carried out extensive and in-depth literature-based studies on the mechanisms for AP and the therapeutic effect of resveratrol on rat AP models, and confirmed that resveratrol could relieve AP-caused damage to the pancreas and the resulting multiple-organ injury.