α-连环素和β-连环素在非小细胞肺癌中的表达及其临床意义

Expressions of α-catenin and β-catenin in human non-small cell lung cancer and their clinical significance

目的探讨α-连环素(α-cat)和β-连环素(β-cat)在非小细胞肺癌(NSCLC)中的表达及其与NSCLC的发生、发展及临床预后的关系。方法应用免疫组化法,观察43例NSCLC患者及7例正常肺组织中的α-cat和β-cat的表达。结果在43例NSCLC中,α-cat和β-cat的异常表达率分别为72.1%和65.1%;α-cat、β-cat异常表达与不同病理分级间和淋巴结有无转移均有显著性差异(P<0.05);α-cat和β-cat异常表达者的生存时间明显少于正常表达者,β-cat异常表达具有独立的预后意义(P<0.05,相对危险度RR=0.330)。结论α-cat和β-cat表达与NSCLC的发生、发展及预后关系密切,可作为评估NSCLC进展及预后的指标。

Objective To investigate the expressions of α-catenin （α-cat） and β-catenin （β-cat） and their relation with development and prognosis of non-small cell lung cancer （NSCLC）. Methods Expressions of α-cat and β-cat were immunohistochemically studied in 43 specimens of NSCLC and 7 cases of normal lung tissues. Results Of the 43 NSCLC cases, the abnormal rate of α- cat and β- cat expression was 72.1% and 65.1%, respectively. Differentiation and lymph node involvement had a significantly positive correlation with abnormal expression of α-cat or β-cat （P〈0.05）. The survival time was significantly shorter in patients with α-cat or β-cat abnormal expression than in those with normal α-cat or β-cat expression, β-cat could serve as an independent prognosis factor （P〈0.05）. Conclusion The expressions of α-cat and β-cat are closely correlated with the occurrence, development and prognosis of NSCLC. α-cat and β-cat may be used as indicators for development and prognosis of NSCLC.