登革热药物防治研究进展

Recent advances in drug prevention and therapy of dengue virus infection

登革热作为一种全球性热带传染病,其防治已成为全世界难题。抗体依赖的感染增强作用以及对病毒致病机制的尚未完全阐明均阻碍了登革热预防与治疗药物的发展应用,目前并无临床可用的特异性预防与治疗药物,但近年来,随着登革热发病机制以及治疗方法研究的不断深入,在登革热药物防治方面的研究有了新进展。为更好地认识登革热以及其药物防治研究现状,本文就登革热药物防治方面的最新进展以及存在的主要问题作一综述。

As a tropical infectious disease, the dengue fever is now one of the most important arthropod-borne diseases from a medical and public health perspective. Antibody-dependent enhancement of dengue virus infection and the unclear pathogenesis mechanism hamper the prevention and treatment of the disease. No efficient preventative and therapeutic drugs are available now,but much progress has been made in the last few years in the drug prevention and therapy of dengue fever. To better understand the current situation, this article reviews the recent advances in the development of anti-dengue vaccines, smallmolecule drugs,monoclonal antibodies and the relevant problems.