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Kupffer细胞在肝移植缺血再灌注损伤中的双重作用 被引量：2

Paradoxical role of Kupffer cells on ischemia/reperfusion injury in liver transplantation
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摘要 Kupffer细胞是定居于肝内的巨噬细胞，在肝移植缺血再灌注损伤中发挥着重要的作用，门静脉恢复血流后刺激Kupffer细胞激活，释放活性氧族、多种炎性介质和细胞因子，对肝脏造成损伤。另一方面又可上调HO—1的表达，保护肝脏缺血再灌注损伤，因此，Kupffer细胞在肝移植缺血再灌注损伤中发挥着双重效应。 Kupffer cells, the resident macrophages of the liver, play an important role in ischemia/reperfusion （I/R） injury in liver transplantation. Ischemic liver is reperfused through portal vein, and then Kupffer cells are activated. The liver is damaged by the released reactive oxygen species, inflammatory mediators and cytokines. On the other hand, upregulation of HO-1, induced by the activated kupffer cells, exerts a cytoprotective function for the I/R injury in liver transplantation models. Thus, Kupffer cells play the dual role on I/R injury in liver transplantation.
作者 黄汉飞 曾仲
机构地区 昆明医学院第一附属医院器官移植中心
出处 《国际外科学杂志》 2009年第2期94-97,共4页 International Journal of Surgery
基金 基金项目：云南省应用基础研究面上项目（No.2007C137M） 云南省科技厅-昆明医学院应用基础研究联合专项基金项目（No.2007C0009R）
关键词 KUPFFER细胞 缺血再灌注损伤 肝移植 Kupffer cells ischemia/reperfusion injury liver transplantation
分类号 R657.3 [医药卫生—外科学] R730.5 [医药卫生—肿瘤]
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参考文献25

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国际外科学杂志
2009年 第2期

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