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翻译控制肿瘤蛋白与肿瘤关系研究进展 被引量：3

Advance in relationship between translationally controlled tumor protein and tumor
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摘要 翻译控制肿瘤蛋白（TCTP）是一种具有高度保守性和同源性的蛋白，广泛表达于所有真核有机体，其表达在转录和翻译水平受调节。在肿瘤中，TCTP参与调控细胞周期和增殖、抗凋亡以及肿瘤逆转，并与化疗耐药相关，有望成为抗肿瘤治疗靶标和肿瘤逆转靶标，为肿瘤治疗提供新思路。 Translationally controlled tumor protein（TCTP） is a highly conserved and homologous protein that is widely expressed in all eukaryotie organisms and regulated at both the transcriptional and the translational level. TCTP participates in the regulation of cell cycle and proliferation, anti-apoptosis, and tumor reversion in tumor; it also correlates with chemo-resistance. It may become potential targets of anti-tumor therapy and tumor reversion and provides a novel ideal for cancer therapy.
作者 王双佳 孙备 陈华
机构地区 哈尔滨医科大学附属第一医院肝胆胰外科
出处 《国际外科学杂志》 2009年第2期134-137,共4页 International Journal of Surgery
关键词 翻译控制肿瘤蛋白 抗凋亡 抗肿瘤 Translationally controlled tumor protein anti-apoptosis anti-tumor
分类号 R730.2 [医药卫生—肿瘤]
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参考文献21

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  • 3Thiele H, Berger M, Skalweit A, et al. Expression of the gene and processed pseudogenes encoding the human and rabbit translationally controlled tumour protein (TCTP) [ J]. Eur J Biochem, 2000, 267(17) :5473-5481.
  • 4Chung S, Kim M, Choi W, et al. Expression of translationally controlled tumor protein mRNA in human colon cancer[ J ]. Cancer Lett, 2000, 156(2) :185-190.
  • 5Tuynder M, Susini L, Prieur S, et al. Biological models and genes of tumor reversion: cellular repoogramming through tpt1/TCTP and SIAH-I[J]. Proc Natl Acad Sci USA, 2002, 99 (23) : 14976- 14981.
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同被引文献16

  • 1雷俊华,曾江正,周东升,洪涛,何志惠.胃癌组织中抗凋亡蛋白livin的表达及临床意义[J].现代预防医学,2012,39(22):5906-5908. 被引量：2
  • 2吕素芳,郭广君,蔡永萍.翻译控制肿瘤蛋白(TCTP)研究进展[J].科学技术与工程,2006,6(4):424-428. 被引量：8
  • 3孙晶,吴毓,王继红,李庆伟.受翻译调节的肿瘤蛋白的结构与功能[J].中国生物化学与分子生物学报,2006,22(8):603-608. 被引量：3
  • 4Gross B, Gaestel M, Bohm H, et al. eDNA sequence coding for a translationally controlled human tumour protein[J]. Nucleic Acids Research, 1989, 17(20): 8367.
  • 5Thaw P, Baxter N J, Hounslow A M. Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones[J]. Nat Struct Biol, 2001, 8 (8): 701-704.
  • 6Sanchez J C, Schaller D, Racier F, et al. Translationally controlled tumor protein: A protein identified in several nontumoral cells including erythrocytes[J]. Electrophorisis, 1997, 18 (1): 50-155.
  • 7Bohm H, Benndorf R, Gaestel M, et al. The growth related-protein P23 of the Ehrlich ascites tumor:translational control ,cloning and primary structure[J] . Biochem Int ,1989,19 (2) :277-286.
  • 8Yenofsky R, Cereghini S, Krowczynska A, Brawerman G Regulation of mRNA utilization in mouse erythroleukemia cells induced to differentiate by exposure to dimethyl sulfoxide[J]. Mol Cell Biol, 1983, 3 (7): 1197-1203.
  • 9Chung S, Kim M, Choi W, et al. Expression of translationally controlled tumor protein mRNA in human colon cancer[J]. Cancer Lett, 2000, 156(2): 185-190.
  • 10Tuynder M, Susini L, Prieur S, et al. Biological models and genes of tumor reversion: cellular reprogramming through tptl/TCTP and SIAH-I[J]. Proc Natl Acad Sci USA, 2002, 99(23): 14976-14981.

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国际外科学杂志
2009年 第2期

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