乳腺癌组织PRL-R表达与肿瘤进展的相关性研究

Correlation between the expression of PRL-R and advancement of breast cancer

目的:探讨乳腺癌组织PRL-R表达与肿瘤进展间的相关性,并分析其可能影响因子。方法:免疫组织化学法检测130例乳腺癌患者原发灶标本蜡块中PRL-R表达,并与肿瘤大小、腋窝淋巴结转移和病理分期三大肿瘤进展指标展开相关性分析。结果:把上述肿瘤进展指标均分为1～3度3个亚层(其病期从早到晚依次递进),则存在共同特点:2度亚层PRL-R表达阳性率>1度亚层(分别为76.3%vs55.3%,83.3%vs61.7%,76.2%vs45.0%,P均<0.05),而2和3度亚层间PRL-R表达阳性率差异无统计学意义,P均>0.05。另外,上述"1度"和"2度"亚层间PRL-R阳性率差异仅限于在ER阴性病例出现(分别为70.3%vs38.9%,85.7%vs42.9%,66.7%vs27.3%,P均<0.05)。结论:在病期较早阶段,PRL-R表达阳性随肿瘤进展呈增高趋势。病期早晚和ER表达是影响乳腺癌组织PRL-R表达与肿瘤进展间相关性的混杂因素。

OBJECTIVE： To investigate the correlation between the expression of PRL- R and the advancement of breast cancer, and furthermore analyze it＇s potential confusing factors. METHODS： The expression of PRL-R was detected in primarily tumor paraffin blocks of 130 female breast cancer patients through the immunohistochemieal method and the correlation between the expression of PRL-R and the main progressive-indicators including tumor size, axillary node metas tasis and pTNM phase was analysed. RESULTS： When the main progressive-indicators above-mentioned were devided into three grades （level 1-level 3）according their progressive levels, the same regular patterns were found： the expressions of PRL-R were greater in level 2 patients than those in level 1 patients （76.3% vs 55.3%, 83.3% vs 61.7% and 76.2% vs 45.0%respectively, all P〈0.05）, but there was no difference between the expressions of PRL R in level 3 and level 2 patients （all P〉0.05）. Moreover, the differences between the expressions of PRL-R in level 1 patients and level 2 patients could only be seen in ER negative stratification（70.3% vs 38.9%, 85.7% vs 42.9% and 66.7%vs 27.3%respectively,all P〈0.05）. CONCLUSIONS： In relative early stage of the disease, the positive expression of PRL-R in primarily tumor is promoting together with the progression of breast cancer. The progressive state of tumor and the expression of ER are two factors confusing the correlation between the expression of PRL-R and the advancememt of breast cancer.