黏液纤维肉瘤7例临床病理分析

Clinicopathologic features of myxofibrosarcoma:a report of 7 cases

目的探讨黏液纤维肉瘤临床病理特点。方法收集7例黏液纤维肉瘤患者的临床及病理资料,并对手术切除的标本进行多种抗体免疫组织化学染色,抗体包括CD117、CD34、CD99、actin、S-100蛋白、vimentin等。结果黏液纤维肉瘤多见于男性,年龄37～72岁,中位年龄52岁,主要以不完全纤维性间隔的多结节行为为特征性表现,黏液区与细胞密集区交错排列,细胞密集区可见特征性曲线型血管,肿瘤细胞围绕在其周围排列。免疫表型:vimentin、CD99阳性,其他抗体多呈阴性。结论黏液纤维肉瘤为一侵袭性较强的软组织肉瘤,与多种黏液性肿瘤需要鉴别,易局部复发,宜采取以手术切除为主的综合性治疗。

Purpose To investigate the clinical and pathologic features of myxofibrosarcoma. Methods Clinicopathologic data were collected in 7 cases of myxofibrosarcoma. All specimens were stained by immunohistochemical method with a panel of antibodies including CD117, CD34, CD99, actin, S-100 and vimentin. Results Myxofibrosarcoma predominantly affected male patients. Age ranged from 37 to 72 years old （ mean 52）. The tumor cells showed a muhinodular growth pattern and were all characterized by alternation between hypercellular areas and myxoid areas. Characteristic curvilinear vessels, around which tumor cells were often concentrated, were noted in hypocellular areas. Immunohistochemically, the neoplastic cells were diffusely positive for vimentin and five cases expressed CD99. Conclusions Myxofibrosarcoma is an aggressive soft tissue sarcoma and has a high rate of local recurrence. Combined modality is recommended to control the relapse of the disease. More attention should be paid in the daily practice in order to differentiate it from other tumors.