延肾1号冲剂对肾缺血再灌注损伤大鼠肾功能的影响

Effect of Yansheng No. 1 granule for renal function of rat with renal ischemia reperfusion injury

目的观察延肾1号冲剂对肾缺血再灌注损伤大鼠肾功能的影响。方法将72只大鼠随机分为假手术组、对照组、治疗组,各24只。治疗组给予延肾1号冲剂灌胃,用药量为2g/(kg·d)。假手术组及对照组灌胃以相应量的自来水。检测大鼠缺血1h、再灌注24、48h血尿素氮(BUN)、肌酐(Cr)的变化情况,并进行肾脏病理学观察。结果再灌注24、48h后治疗组、对照组与假手术组BUN、Cr比较均有统计学意义(P<0.01);治疗组、对照组BUN、Cr均明显降低,2组比较差异均有统计学意义(P<0.01)。且治疗组肾小管的病变及修复程度均较对照组、假手术组好转。结论延肾1号冲剂对肾缺血再灌注损伤大鼠肾功能有明显的保护作用。

Objective To observe the effect of Yansheng No. 1 granule for renal function of rat with renal ischemia reperfusion injury. Methods 72 rats were randomly divided into three groups including sham group, control group and treatment group. Rats in treatment group accepted Yansheng No. 1 granule, 2g/kg. d. Rats in sham group and control group accepted corresponding tap water. Changes of BUN and Cr in rat lh ischemia, 24h and 48h of reperfusion were recorded. And renal pathology was observed. Results BUN and Cr in control group and treatment group obviously decreased in comparison with those in sham! group （ P 〈 0.01）. Improvement of pathological changes and repaired extent in treatment group was superior to that in sham group and control group （ P 〈 0.05）. Conclusion Yansheng No. 1 granule has protection on renal function of rat with renal ischemia repeffusion injury.