消渴安糖方对2型糖尿病患者胰岛素受体的影响

Effect of Xiaoke Antang Formula on Insulin Receptors in Patients with Type 2 Diabetes Mellitus

目的:研究消渴安糖方对2型糖尿病患者血红细胞胰岛素受体活性和数量的影响,探讨消渴安糖方的降糖机制。方法:将40例初发2型糖尿病患者随机分为治疗组(消渴安糖方联合胰岛素皮下注射治疗组)和对照组(胰岛素皮下注射治疗组),均用药2周,观察两组临床疗效,分别观察治疗指标:糖化血红蛋白(HbA1c)、空腹胰岛素(FIns)、胰岛素功能指数(HOMA-IS)、胰岛素抵抗指数(HOMA-IR)以及红细胞胰岛素受体k1,r1,r2,k2值的变化情况,进行对比分析。结果:两组疗效比较无显著性差异(P>0.05),但治疗组在改善患者FINS、HOMA-IR、HOMA-IS以及胰岛素受体数量方面均优于对照组(P<0.05或P<0.01)。结论:消渴安糖方联合胰岛素治疗不仅可以降血糖,改善糖尿病患者临床症状,而且可以通过改善胰岛素受体的活性和数量来减轻糖尿病患者的胰岛素抵抗程度。

Objective： To study the effect of Xiaoke A ntang formula on activity and quantity of insulin receptors of erythrocytes in patients with type 2 diabetes mellitus and to investigate the hypoglycemic mechanism of Xiaoke A ntang formula. Methods： Forty in-patients with new-onset Type 2 diabetes mellitus were randomized to receive subcutaneous injection of insulin alone （control group） or in combination with Xiaoke Antang formula （treatment group） for 2 weeks. Changes in efficacy measures, including HbAIc, Fins, HOMA-IS, HOMA-IR and values of k1, r1,r2 and k2 （insulin receptors of erythrocytes） were observed and comparatively analyzed. Results： There was no significant difference in efficacy between the two groups （P 〉 0.05 ）. However, the improvement of Fins, HOMA- IR, HOMA-IS and the quantity of insulin receptors in the treatment group were greater compared with the control group （P 〈0.05 or P〈0.01 ）. Conclusions： Treatment with Xiaoke Antang formula plus subcutaneous injection of insulin may improve the clinical symptoms of diabetes by decreasing blood glucose and reduce insulin resistance by improving the activity and quantity of insulin receptors in patients with diabetes.