^(153)Sm-EDTMP 的纸色层行为研究

STUDY ON THE PAPER CHROMATOGRAM OF 153 Sm EDTMP

采用两种新的１５３Ｓｍ－ＥＤＴＭＰ纸色层展开体系：Ｖ（氨水）∶Ｖ（甲醇）∶Ｖ（水）＝０．１∶２∶４（ｐＨ＝１１．０－１４．０）和Ｖ（氨水）∶Ｖ（丙酮）∶Ｖ（水）＝０．２∶０．５∶４（ｐＨ＝７．０－９．０）来研究１５３Ｓｍ－ＥＤＴＭＰ的纸色层行为。新体系比原有体系Ｖ（吡啶）∶Ｖ（乙醇）∶Ｖ（水）＝１∶２∶４的展开时间短，分离效果好。其中（氨＋丙酮＋水）体系分离效率高，标记峰不存在拖尾，展开时间缩短１．５ｈ以上，适合于制备１５３Ｓｍ－ＥＤＴＭＰ的产品质量分析。

Two kinds of new rapid paper chromatography system, which are V (ammonium solution)∶ V (CH 3OH)∶ V (H 2O)=0.1∶2∶4 (pH=11.0-14.0) and V (ammonium solution)∶ V (CH 3COCH 3)∶ V (H 2O)=0.2∶0.5∶4 (pH=7.0-9.0) are used for 153 Sm EDTMP radiochemical purity determination. Compared with the old system( V (C 5H 5N)∶ V (C 2H 5OH)∶ V (H 2O)=1∶2∶4),the new ones reduce sharply the developing time and get an efficient separation of 153 Sm EDTMP from 153 SmCl 3, it is especially the system V (ammonium solution)∶ V (CH 3COCH 3)∶ V (H 2O)=0.2∶0.5∶4 (pH=7.0-9.0) that reduces the developing time about 1-2 h.