邻苯二甲酸酯代谢研究进展

Research Progress in Metabolism of Phthalate Esters

邻苯二甲酸酯主要用作塑料增塑剂,普遍存在于环境中。动物实验表明邻苯二甲酸酯具有内分泌干扰作用,已在尿液、血液和精液等体液中检测到邻苯二甲酸酯。邻苯二甲酸酯在体内的代谢研究是内暴露评价的基础,该文对邻苯二甲酸酯的代谢研究进展进行了综述,指出了邻苯二甲酸酯主要代谢路径和在尿液中的代谢产物,比较了不同人群尿液中邻苯二甲酸酯代谢物的浓度水平。

Phthalate esters are commonly used as plasticizers in many products. They have become widely spread in the environment. Several animal studies have showed that phthalate esters possess endocrine disrupting effects. Phthalate esters have been found in body fluid such as urine, blood and semen. As the base of internal exposure assessment, metabolism of phthalate esters was reviewed in the paper. The main metabolism pathways for phthalate esters and their metabolites in urine were summarized and the levels of metabolites of phthalate esters in different people were compared.