[α-^(15)N]-dl-色氨酸的合成

Synthesis of [α-^(15)N]-dl-tryptophan

以15N－甘氨酸为原料，用铝镍合金作还原剂，经多步反应合成[α－15N]－dl－色氨酸，总产率为46．9％，15N的丰度约为93％。终产物的理化性质与色氨酸标准品一致，并经元素分析、MS、UV和纸层析证实。

[α -15N]-dl-tryptophan was synthesized by the use of Al-Ni alloy catalytichydrogenation from 15N-glycine via several steps. The overall yield of the finalproduct was 46.9% and the abundance of 15N was about 93%. The physicochemicalproperties of the synthetic compound obtained were the same as those of the standardtryptophan. Its structure were confirmed by the elemental analyses, MS, UV andpaper chromatography.