卵巢颗粒细胞瘤临床分期对预后和复发的影响

To Study the Effect of Clinical Stage Factors on Prognosis and Recrudesce for Granulosa Cell Tumors of Ovary

目的探讨卵巢颗粒细胞瘤临床分期对其预后和复发的影响。方法回顾性分析吉林大学第二医院1985-2004年收治的保留资料完整的43例卵巢颗粒细胞瘤患者的临床分期因素及预后的关系,并对复发及未复发患者进行上述因素的比较。结果全组总的5年和10年生存率别为95.3%和76.7%。临床分期为Ⅰ期者5年和10年生存率分别为96.4%和92.9%,Ⅱ-Ⅳ期为60.0%和20.0%,分别比较,差异有显著性。不同临床分期的复发情况分别比较,差异有显著性（P〈0.05）。复发及未复发,早期复发及晚期复发等各因素相比较,临床分期因素差异有显著性。结论卵巢颗粒细胞瘤的临床分期是其预后的重要相关因素。目前根据临床分期因素尚难以预测患者是否会远期复发。

Objective To study the effect of clinical stage factors on prognosis and recrudesce for granulosa cell tumors of ovary. Methods The clinical records and tumor sections with granulosa cell tumor of the ovary between 1985 and 2004 were reviewed. The relationship among clinical stage were analysed retrospectively. Patients with recurrent tumors （ REC ） were compared with patients who remained without diseases （NED）. Results The overall 5 and 10 years survival rates were 95.3% and 76.7%. The survival rates in stage Ⅰ were 96. 4% and 92.9% after 5 and 10 years respectively and from stage Ⅱ to stage Ⅳ, the survival rates were 60.0% and 20.0%. There were significant difference between stage and recurrence （P 〈0.01 ）. When REC and NED were compared, the significant difference is in stage （P 〈 0.05 ）. When late recurrence tumors and early recurrence tumors were compared, the significant differences were in stage （ P 〈 0.01 ）. Conclusion Tumor stage and cellular atypia and high mitotic rates are the clinical and pathologic prognostic factors in granulosa cell tumor. At present, it＇s difficult to predict late recurrence using clinical and pathologic parameters