视网膜母细胞瘤Ki67表达的临床及病理学意义

The clinico-pathological significance of expression of Ki67 in retinoblastoma

目的分析探讨Ki67在视网膜母细胞瘤(RB)中的表达的意义以及与临床和病理指标之间的关系。方法选取山东省立医院、济南市第二人民医院、济南市施尔明医院以及济南军区总医院等4所医院1990～2004年经病理诊断证实为RB的患者46例,对其中的22例取得保存完好的病理蜡块,采用免疫组织化学PV9000两步法检测Ki67在RB标本中的表达,并结合临床、病理指标进行SPSS统计软件相关性分析。结果Ki67在RB中的阳性表达与临床分期呈正相关(P<0.05),与患者视神经侵犯程度、性别、年龄、眼别及组织学分型无统计学差异(P>0.05)。结论Ki67在RB中的阳性表达与视神经侵犯程度、患者性别、年龄、眼别及组织学类型无统计学差异。

Objective To investigate the clinico-pathological significance of expression of Ki67 in retinoblastoma. Method The clinical and pathologic data of 46 retinoblastoma patients admitted in 4 hospitals of Jinan city from 1990 to 2004yr were reviewed; in 22 cages With well conserved paraffin blocks was detected the expression of Ki67 in retinoblastoma （RB）, by using the immunohistochemistry method. All data were analyzed statistically with SPSS. Result The expression of Ki67 in refinoblastoma had a positive correlation to optic nerve invasion （P〈0.05）, but not to clinical stages, sex,age, eye distinction or tumor differentiation（P〉0.05）. Conclusion The expression of Ki67 in retinoblastoma has a positive correlation to clinical stages, but not to optic nerve invasion, sex, age, eye distinction or tumor differentiation.