CerbB-2与ER在乳腺癌中表达的相关性及临床意义

The Relationship and Clinical Significance in Expression of CerbB-2 and ER in Breast Cancer

目的:探讨乳腺癌表皮生长因子受体(CerbB-2)、雌激素受体(ER)表达的相关性及临床意义。方法:150例原发乳腺癌石蜡切片标本,采用免疫组织化学方法。结果:CerbB-2的阳性率为29.33%,CerbB-2与腋淋巴结转移相关(P<0.01),与临床分期呈正相关(P<0.01),与ER呈负相关(P<0.01)。结论:乳腺癌的CerbB-2与ER检测对于临床治疗及辅助判断患者的预后有重要意义。

Objective：To observe the relationship and clinical significance in expression of CerbB - 2 and ER in breast cancer. Methods： 150 cases paraffin section specimen of primary breast cancer . Immunohistochemistry was applied. Results： The positive rate of CerbB- 2 was 29.33 %, CerbB- 2 was correlated with the axillary lymph nodes metastasis（ P 〈 0.01 ）. CerbB - 2 was positive correlated with clinical classification （ P 〈 0.01 ）, significant negative correlated with ER（P 〈 0.01 ）. Conclusions： The detection of CerbB- 2 and ER has impor- tant significant in clinical treatment and prognosis.